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It was the discovery of melatonin synthesis in endocrine body organs, specifically the pineal gland, neural structures, and also immunocompetent cells such as T lymphocytes, NK cells, and mast cells that triggered the brand-new strategies to the unifield signal regulation of homeostasis, which, at the turn of the 21st century, result in the creation of a new essential biomedical discipline - neuroimmunoendocrinology.
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